Sevgilisi Mary Jane'den ayrılan Peter ona gerçek kimliğini açıklayıp açıklamamak arasında kaldığı için oldukça zor bir dönem geçirmektedir. kararsızlık içine düştüğü bu esnada Mary Jane'in, patronun oğlu John'la birlikte olmaya başlaması iyice canını sıkar. Bunlara, halasının mali sıkıntıları ve hayattaki tek dostu Harry Osborne'un, babasının ölümünden kendisini sorumlu tuttuğu için Peterdan uzaklaşması onu depresyonun eşiğine getirmiştir. Bu esnada, yeni düşmanı Doktor Ahtapot'un ortaya çıkmasıyla Peter Parker'ın hayatı içinden çıkılmaz bir hal alacaktır.
Spider-Man / Peter Parker
Mary Jane Watson
Harry Osborn
Doc Ock / Otto Octavius
May Parker
J. Jonah Jameson
Rosalie Octavius
John Jameson
Dr. Curt Connors
Joseph 'Robbie' Robertson
Louise
Mr. Aziz
Green Goblin / Norman Osborn
Ben Parker
Hoffman
Miss Brant
Snooty Usher
Dr. Davis
Mr. Ditkovitch
Ursula
Raymond
Elevator Passenger
Mr. Jacks
Man Dodging Debris
Dr. Isaacs
Garbage Man
Receptionist
Henry Jackson
Man on Balcony
OsCorp Executive
Mrs. Jameson
Society Woman
Houseman
Woman at Web
Skeptical Scientist
OsCorp Representative
Injured Scientist
Mrs. Watson
Stage Manager
Pizza "Heist" Witness
Boy saved by Spider-Man
Girl saved by Spider-Man
Poker Player
Amazed Kid
Amazed Kid
Theater Traffic Cop
'Algernon'
'Jack'
Violinist
Doctor
Chainsaw Doctor
Clawing Nurse
Screaming Nurse
Man at Fire
Woman at Fire
Child in Burning Building
Fireman
Fireman
Train Conductor
Boy with Mask
Boy with Mask
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
Train Passenger
NYPD Officer (uncredited)
Pizza Man (uncredited)
Chinese Daughter (uncredited)
Train Passenger (uncredited)
Fireman 2 (uncredited)
Piano Player in Planetarium (uncredited)
Little Girl Playing on Steps (uncredited)
Little Boy Playing on Steps (uncredited)
Blue Collar Guy (uncredited)
Pedestrian (uncredited)
Screaming Woman (uncredited)
Columbia University Student (uncredited)
Man at Web (uncredited)
Bearded Doctor (uncredited)
Priest at Mary Jane's Wedding (uncredited)
Pedestrian (uncredited)
Passenger (uncredited)
Parent (uncredited)
Planetarium (uncredited)
Hot Dog Vendor (uncredited)
Victim (uncredited)
Stock Broker (uncredited)
Middle Eastern Taxi Driver (uncredited)
Hot Girl (uncredited)
Train Passenger (uncredited)
Bank Employee (uncredited)
Extra (uncredited)
Robbie's Assistant (uncredited)
Cop (uncredited)
Train Passenger (uncredited)
Phone Booth Girl (uncredited)
Train Passenger (uncredited)
Jane, Engineer (uncredited)
Female Onlooker on Street (uncredited)
Train Passenger (uncredited)
Reporter (uncredited)
Train Passenger (uncredited)
Uptight Businessman (uncredited)
Doc Ock Lab Assistant #2 (uncredited)
Cab Driver (uncredited)
Train Passenger (uncredited)
University Student with Bag (uncredited)
Man Buying 'Spider-Man No More' Newspaper (uncredited)
Executive Producer
Screenplay
Set Decoration
Producer
Producer
Executive Producer
Executive Producer
Producer
Director of Photography
Editor
Original Music Composer
Director
Casting
Production Design
Costume Design
Senior Animator
Production Assistant
Production Assistant
Prosthetics
Screenstory
Screenstory
Screenstory
Art Department Manager
Co-Producer
Orchestrator
Costume Design
Musician
Stunts
Comic Book
Music Editor
Special Effects Supervisor
Grip
Art Direction
Assistant Editor
Art Direction
Art Direction
Stunt Coordinator
Art Direction
Art Direction
Key Hair Stylist
Makeup Artist
Assistant Director
Utility Stunts
Script Supervisor
Visual Effects
Set Production Assistant
Sound Effects Editor
Driver
Sound Mixer
Orchestrator
Executive Producer
Casting Associate
Special Effects
Electrician
Sculptor
Leadman
Assistant Art Director
Construction Foreman
Painter
First Assistant Camera
Hairstylist
Camera Technician
Steadicam Operator
Still Photographer
Construction Coordinator
Art Department Assistant
Production Illustrator
Location Scout
Set Designer
Art Department Coordinator
Production Controller
Set Medic
Production Coordinator
Visual Effects Producer
First Assistant Editor
Sound Designer
Quality Control Supervisor
Software Engineer
Publicist
Hair Department Head
Location Manager
Scoring Mixer
Visual Effects Supervisor
Propmaker
Scenic Artist
Boom Operator
Visual Effects Coordinator
Chef
Craft Service
Transportation Co-Captain
Unit Production Manager
Gaffer
Studio Teachers
Helicopter Camera
Set Costumer
Carpenter
Special Effects Coordinator
Transportation Coordinator
Digital Compositors
Assistant Costume Designer
CG Supervisor
Stunts
Systems Administrators & Support
Production Supervisor
Production Sound Mixer
Sound Effects Editor
Camera Operator
Production Intern
Stand In
Production Accountant
Supervising Sound Editor
Standby Painter
Seamstress
Picture Car Coordinator
Production Office Assistant
Visual Effects Editor
Rigging Gaffer
Makeup Department Head
Additional Music
Digital Producer
Color Timer
Lighting Technician
Sound Editor
Hairstylist
Utility Stunts
Stunts
Stunts
Stunts
Assistant Production Coordinator
Key Grip
Tailor
Fight Choreographer
ADR Editor
Supervising Dialogue Editor
Visual Effects Technical Director
Ager/Dyer
Techno Crane Operator
Wardrobe Supervisor
Lead Animator
Mechanical Designer
Camera Loader
Dolly Grip
Assistant Production Manager
CG Animator
Key Makeup Artist
Animatronics Designer
Set Dresser
Title Designer
Second Assistant Director
Negative Cutter
Musician
Supervising ADR Editor
Assistant Property Master
Set Decorating Coordinator
Key Costumer
Stunts
Sound Recordist
Property Master
Dialogue Editor
Dialogue Editor
Sound Mixer
Comic Book
First Assistant Sound Editor
Stunt Driver
Visual Effects Designer
Stunts
Best Boy Grip
Assistant Accountant
Payroll Accountant
Costumer
Stunt Driver
Second Assistant Camera
Digital Color Timer
Second Unit Director
Animation Director
Senior Animator
Key Production Assistant
Clapper Loader
Scientific Consultant
Graphic Designer
ADR Mixer
Special Effects Technician
Assistant Location Manager
Chief Lighting Technician
Storyboard Artist
Extras Casting
First Assistant Accountant
Additional Second Assistant Director
Key Construction Grip
Foley Supervisor
Stunt Double
Additional Director of Photography
Key Rigging Grip
Production Executive
Second Assistant Accountant
Additional Wardrobe Assistant
Location Assistant
Additional Production Assistant
Creative Director
First Assistant Sound Editor
Medical Consultant
Second Second Assistant Director
Set Painter
Hair Assistant
Compositing Supervisor
Production Assistant
Storyboard Assistant
CG Artist
Researcher
Foley Artist
Dolly Grip
Digital Colorist
Costume Assistant
Assistant Camera
Conductor
Production Secretary
Head of Production
Sequence Lead
Additional Second Assistant Camera
Visual Effects Supervisor
Visual Effects Supervisor
Sound Re-Recording Mixer
Sound Re-Recording Mixer
Special Effects Supervisor
Sound Re-Recording Mixer
Construction Coordinator
Stunt Double
Stunts
Stunts